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Zhang, W., Song, J., Zhang, Y., Ma, Y., Yang, J., He, G., & Chen, S

It is built on a 37-residue modified human amylin / pramlintide-style backbone with three rationally designed substitutions (N14E and V17R to stabilise the central alpha-helix through a salt bridge, P37Y to enhance calcitonin-receptor potency) and N-terminal acylation with a C20 eicosanedioic fatty diacid attached via a gamma-glutamic acid linker

Stress-Response & Cellular Adaptation Models Cellular systems constantly respond to environmental and metabolic stressors

Three entry points into tissue repair instead of one

In individuals with obesity or metabolic dysfunction, amylin signaling may be impaired