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It is often associated with circulating pro-inflammatory cytokines and immune cells
Further, this condition may be associated with a plasma concentration ratio of acylcarnitine/levocarnitine greater than 0.4 or abnormally elevated concentrations of acylcarnitine in the urine
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This difference is significant and apparent during the second timepoint where low carnitine patients experienced an increase in % seizure change as opposed to the % seizure reduction expected from undergoing MAD therapy
It does not mean treatment has failed
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