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A retrospective analysis of 9479 referrals to multi-national liver transplant units gave an event rate of 3.3 million treatment years for non-overdose paracetamol as the aetiology for acute liver failure requiring transplant

The impact of these microbial alterations extends far beyond the stomach, participating in the pathogenesis of various extra-gastric conditions through the disruption of immune homeostasis and induction of gut microbiota alterations

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