Skin texture, lighting, body proportions: all are generated to mimic a plausible journey, often showing a woman in her 40s or 50s, the demographic currently driving Europes GLP-1 interest
Benign adaptation looks mild, intermittent, and self-limiting by comparison
The FDA has approved specific formulations for different indications: semaglutide 2.4 mg (Wegovy), liraglutide 3 mg (Saxenda), and tirzepatide (Zepbound) are approved for chronic weight management, while all are approved for diabetes at different doses
These findings support the concept that glucagon receptor activation may be therapeutically useful when balanced by GLP-1 receptor signaling, although retatrutide currently provides the most prominent evidence for triple receptor agonism
Sig Transduct Target Ther 10 , 239 (2025)