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10.1016/j.apsb.2020.06.016 Summary Keywords thonningianin A, Acetaminophen, acute liver injury, GPx4, endoplasmic reticulum stress, hepatotoxicity Citation Lai S, Ye Y, Ding Q, Hu X, Fu A, Wu L, Cao W, Liu Q, Dou X and Qi X (2025) Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stress

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FOXO4-p53 Disruption Moderate Research Detailed mechanistic studies confirm that FOXO4-DRI achieves its senolytic effects through precise disruption of the protective FOXO4-p53 protein interaction that allows senescent cells to evade apoptosis and persist in tissues

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