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Bacterial infection causes stress-induced memory dysfunction in mice

Lower concentration, larger draw volume per dose

Particularly, TRF2 is essential for inhibiting the ATM kinase signaling pathway, a primary responder to DNA double-strand breaks (Pinzaru et al., 2016)

This indicates that the compound did not kill the cells (Figure 3, Panel A, and Figure 4, Panel A)

It is crucial to note, however, that recent studies highlight significant systemic side effects of MCT4 inhibition due to its broad tissue expression, which may limit its clinical translational potential and necessitate the development of tissue-specific delivery strategies [138]