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It has moved in and out of the FDA's 503A bulk drug substance "Category 2" list (substances compounding pharmacies are barred from using over safety concerns) more than once as the agency's Pharmacy Compounding Advisory Committee has revisited it

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Reconstitution and handling Allow lyophilised material to equilibrate before opening to reduce condensation risk

Vascular issues Though rare, overuse of therapeutic B12 may lead to vascular events: Clots in deep veins Swelling in the legs Risk of pulmonary complications in sensitive groups Tabular View for Quick Recap You should report symptoms early to stop things from getting worse

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