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This combination: Strongly reduces hunger and cravings

Discontinuation rates due to adverse events in TRIUMPH-3 were 9.8% (9 mg) and 13.5% (12 mg) with retatrutide, compared with 4.8% for placebo

Although no clinical studies have directly compared gastric emptying with long- and short-acting GLP-1RAs, their relative effects were illustrated in an animal study comparing liraglutide and exenatide, where the latter was shown to have a profound effect on gastric emptying while liraglutide had very little effect (124, 189)

More importantly, the weight loss associated with GLP-1s is not a welcome symptom in a disease were slowly progressive wasting is common concern

Peptide therapy is not appropriate for everyone, which is why a thorough medical evaluation is important