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Brooks proposed the theory of the lactate shuttle, indicating that lactate can also act as an energy source via oxidative pathways in different organs and cells in an aerobic environment, facilitating metabolic coordination across tissues [8, 9]
Cancer cells may become resistant to platinum-based drugs through multiple mechanisms, including an increased ability to repair platinum-induced DNA damage, neutralization of platinum toxicity, and an increase in drug export (38)
Its often used in conjunction with regenerative medicine techniques such as stem cell therapy to optimize recovery time and improve outcomes
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