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Overall, our results suggest that the AP is responsible for the appetite-suppressing effects of GIPR agonism but that GIP receptors in the hypothalamus underlie the ability of GIPR antagonism to enhance the weight loss effects of GLP-1R and amylin receptor agonists

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We go from fasting saints starving themselves toward God, to a Columbia psychologist in the 1960s who built a whole career on the idea that some people's hunger was simply broken