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Because GLP-1 receptor agonists directly influence pancreatic function, theoretical questions have been raised about whether chronic stimulation of these receptors might contribute to pancreatic pathology, although there is no evidence confirming this mechanism

While thirst itself isnt among the most frequently documented side effects, the gastrointestinal side effects that can lead to dehydration and subsequently trigger thirst are well-documented: Nausea: 12-24% of patients Diarrhoea: 12-22% of patients Vomiting: 2-13% of patients These digestive effects can cause fluid loss and trigger compensatory thirst, making it a secondary effect of the medications primary side effects

Appendix A: Complete search strategy Appendix A: Complete search strategy Embase Classic+Embase 1 exp glucagon like peptide 1 receptor agonist/60446 2 ((glucagon like peptide 1 receptor* or glucagon like peptide one receptor* or GLP-1RA*) adj3 (agonist* or antagonist* or medication* or drug* or agent* or analog*)).mp.19078 3 (semaglutide or liraglutide or exenatide or tirzepatide or albiglutide or dulaglutide or lixisenatide or Ozempic or Wegovy or Rybelsus or Saxenda or Byetta or Adlyxin or Trulicity or Mounjaro).mp