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10.1104/pp.110.1.125 110 ReddyA

Kay SR, Fiszbein A, Opler LA

However, it is worth noting that iron accumulation at the hypothalamic-pituitary level may impair Gonadotropin-releasing hormone neurons and/or pituitary gonadotroph cells and lead to hypogonadotropic hypogonadism, which is characterized by low levels of gonadotropins (FSH and LH) and testosterone, thus indirectly affecting testicular function [67, 68]