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Matrix metalloproteinase (MMP) 9 transcription in mouse brain induced by fear learning

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When the active substance circulates via the bloodstream, a fraction of the active substance will be metabolized or excreted, and consequently the concentration of the active substance in the body will decrease over time (see figure above)

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The COMT connection: Another enzyme affected by poor methylation is COMT (catechol-O-methyltransferase), which breaks down and clears neurotransmitters like dopamine and adrenaline

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