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Obesity is a disease in which the mechanisms that normally control hunger and fullness are disrupted because of genetic mutations
The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes
Weight-loss outcomes depend on starting weight, dose, adherence, diet, physical activity, medical history, and individual biology
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Some patients will use Wegovy until they reach their weight loss goal and then switch to maintenance therapy, others will stay on a long term to maintain weight loss
