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However, groups switched from WD to LD (WD/LD-V, WD/LD-T) tended to show greater alpha diversity compared to the control groups (WD/WD-V and LD/LD-V), which was not surprising since these animals experienced the most diet transitions with variable nutrient resources during their lifetime

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For patients who simply want periodic supplementation without a clinical deficiency, the frequency is more flexible

This uncertainty is one of the challenges with using compounds that lack regulatory approval

References: Office of Dietary Supplements, National Institutes of Health