Ischemic heart disease including myocardial infarction and chronic ischemia could potentially benefit from the peptide's cardioprotective effects, enhanced coronary angiogenesis, and anti-arrhythmic properties demonstrated in animal models
However, these conditions do not fully capture the physiological context in which the microenvironment drives metabolic dysregulation and competition for bioenergetic resources, nor do they address the complexities introduced by immunosuppression
Larazotide treatment attenuated the enhanced intestinal permeability and blocked the migration of immune cells from the intestine to the joints (graphical summary in Supplementary Fig
Meanwhile, it operates without disrupting baseline cellular stability
Yang Y, Lin J, Guo S, Xue X, Wang Y, Qiu S, et al