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J Personalized Med 2024;14(5):489

This lack of clear association between brain glutathione levels and aging is important because it shows that glutathione may not be the limiting factor in cognitive changes in aging

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Numerous recent studies have demonstrated the critical role of oxidative stress, abnormal lipid metabolism, endoplasmic reticulum stress, various forms of cell death (including apoptosis, necroptosis, and ferroptosis), intestinal microbiota dysbiosis, liver immune response, cell autophagy, and epigenetic abnormalities in the pathogenesis of ALD