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The studies also had some shortcomings, as some only administered fluoxetine at the end of pregnancy and could not assess the effects of the drug throughout the entire pregnancy period, some did not explore the specific mechanisms of fluoxetine-induced fetal acidosis, hypocalcemia, and altered maternal estradiol metabolism, and some failed to assess the maternal and fetal health status over a long-term follow-up period

The in vivo study indicated that the probiotic milk fermented with Lactobacillus helveticus MTCC 5463, Streptococcus thermophilus MTCC 5462, and Lacticaseibacillus rhamnosus MTCC 5946 exerted a better anti-obesity effect ( Lactobacillus helveticus MTCC 5463 had anticancer effects ( Bifidobacterium animalis BB-12 and pomegranate juice decreased the anxiety-related behaviors and increase the sleep quality through the gut-brain axis ( Limosilactobacillus J20 and J23 that were shown as the most proteolytic strains, presented angiotensin converting enzyme, thrombin enzyme and micellar solubility of cholesterol inhibitory activities and potential cardio-protective effects ( Propionibacterium freudenreichii CIRM-BIA129, a probiotic strain known for its anti-inflammatory properties,-fermented milk prevented colitis potentially with its fat content ( In vivo analyses examined a fermented milk product made with four types of LAB revealed that the product effectively reduced allergy symptoms by regulating the immune response