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By immunohistochemical staining and western blot analysis, an increase in MMP-9 expression in the CS group was observed compared to that in the control group, and pretreatment with GHK-Cu reduced MMP-9 expression compared to that in the CS group (Figures 2AC)

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Furthermore, while the mechanisms of action of PhGs are explored, the available data on in vivo targets and the pharmacokineticpharmacodynamic relationships of these compounds are still limited

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