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Inflammation engulfs a substantial amount of oxygen, leading to hypoxia and acidic conditions in the 1 system [13], which subsequently triggers the generation of reactive oxygen species (ROS), angiogenesis, and infiltration by inflammatory cells

Oxytocin represents a therapeutic option that does not require oral administration and has generally been noted to be well tolerated and potentially efficacious in several placebo-controlled trials

CpG methylation induces histone deacetylation, chromatin remodeling, and gene silencing through a transcription repressive complex, which includes SMRT (silencing mediators of retinoic acid and thyroid receptor), mSin3a, RbAp46/48, and the formation around mSin3a The two histone deacetylases HDAC1 and HDAC2