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10.1093/molbev/mst010 33
Lysosomal enzyme activity modulation Beyond gross membrane disruption, a more nuanced strategy involves interfering with the activity of lysosomal enzymes to alter cellular metabolism and drug handling
This chronic disease is very difficult to diagnose and has very limited treatment options
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Certain populations face higher deficiency risk: vegetarians and vegans (B12 is primarily found in animal products), adults over 50 (decreased stomach acid reduces B12 absorption), individuals with digestive disorders like Crohn's disease or celiac disease, and those taking medications like metformin or proton pump inhibitors
