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Abbreviations ACSL4: Acyl-CoA synthetase long-chain family member 4 AHR: Aryl hydrocarbon receptor ARE: Antioxidant response element AST: Aspartate aminotransferase ALT: Alanine aminotransferase AKI: Acute kidney injury Akt: Protein kinase B AOX: Aldehyde oxidase ASC: Apoptosis-associated speck-like protein containing a CARD ATF6: Activating transcription factor 6 ATP: Adenosine triphosphate AI: Artificial intelligence Bax: Bcl-2-associated X protein Bcl-2: B-cell lymphoma 2 BUN: Blood urea nitrogen CAT: Catalase CHOP: C/EBP homologous protein CYP1A1: Cytochrome P450 family 1 subfamily a member 1 CYP450: Cytochrome P450 reductase DOPAC: 3,4-Dihydroxyphenylacetic acid DIC: Disseminated intravascular coagulation DQ: Diquat eIF2: Eukaryotic initiation factor 2 EMT: Epithelial to mesenchymal transition ER: Endoplasmic reticulum ERK1/2: Extracellular signal-regulated kinase FOXO3a: Forkhead box o3a FSP1: Ferroptosis suppressor protein 1 FTH1: Ferritin heavy chain 1 GLUT2: Glucose transporter 2 GPX: Glutathione peroxidase GRP78: Glucose-regulated protein 78 GSH: Glutathione GSSG: Glutathione disulfide HMGB1: High mobility group box 1 HO-1: Heme oxygenase 1 HSPB1: Heat shock protein family B (Small) member 1 IRE1: Inositol-requiring enzyme 1 IB: Inhibitor of kappa B IKK: IB kinase JNK: Jun N-terminal kinase Keap1: Kelch like ECH-associated protein 1 MAPK: Mitogen-activated protein kinase MDA: Malondialdehyde mTOR: Mechanistic target of rapamycin MyD88: Myeloid differentiation primary response 88 NADH: Nicotinamide adenine dinucleotide NADPH: Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor-B NLRP3: NACHT, LRR and PYD domains-containing protein 3 NO: Nitric oxide NQO1: NAD(P)H: Quinone oxidoreductase 1 Nrf1: Nuclear respiratory factor 1 Nrf2: Nuclear factor erythroid 2related factor 2 O: Oxygen p38MAPK: P38MAP kinase PERK: Protein kinase R-like endoplasmic reticulum kinase P2X4: P2X purinoceptor 4 PARP: Poly (ADP-ribose) polymerase PGC1: Peroxisome proliferator-activated receptor coactivator 1- PUFA-PE: Polyunsaturated fatty acids-phosphatidyl Ethanolamine PI3K: Phosphoinositide 3-kinase ROS: Reactive oxygen species RNS: Reactive nitrogen species rhsTM: Recombinant human soluble thrombomodulin SGLT1: Sodium-glucose cotransporter 1 SIRT1: Sirtuin 1 SLC7A11: Solute carrier family 7member 11 SOD: Superoxide dismutase sTM: Soluble thrombomodulin TFAM: Mitochondrial transcription factor A TFR1: Transferrin receptor 1 TGF-1: Transforming growth factor- 1 TLR4: Toll-like receptor 4 TOPPS: Tetrahydro-2,2-bipyridyl-1,1-dioxide-5,5-dicarboxylic acid TNF-: Tumor necrosis factor- -GT: -Glutamyl transferase References Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A

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Stay Informed Monitor emerging clinical trial data for CagriSema and other combinations Follow regulatory developments as new therapies approach approval Engage with continuing education on peptide mechanisms and applications 2

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