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In a subsequent study, lean Gipr AP-KO and Gipr AP-GFP mice were switched to an HFD on the same day as initiating 10 days of daily injections with either LIRA (or VEH) alone, or LIRA (or VEH) plus GIPR antagonist peptide (GIPR-antag) 6

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maximum use concentration of 0.10.6% in topical products Recommended Dosage Oral supplement : 250500 mg daily (some protocols use up to 1,0002,000 mg initially) Topical formulations : 0.10.6% of total formula, added during cool-down phase Classic liposomal or higher-dose forms may be used under medical/generic supervision for accelerated results

Outcomes were ascertained from routinely collected health records (e.g., registers, EHR, claims)

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