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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
Repeated temperature cycling accelerates degradation noticeably more than steady storage at any single temperature inside the recommended bands
However, its important to approach its usage with caution, following recommended dosages and monitoring for potential side effects
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