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Modulates Gene Expression in Melanocytes It suppresses MITF (Microphthalmia-associated transcription factor), a regulator of tyrosinase and other pigmentation-related proteins
Typical applications include glutathione S-transferase phase-II conjugation assays, glutathione peroxidase and glutathione reductase coupled assays, GSH/GSSG ratio determination as a redox readout in cultured cells, protein S-glutathionylation studies, and ferroptosis models where glutathione availability governs glutathione peroxidase 4 activity and therefore phospholipid hydroperoxide handling (Yang et al., Cell, 2014)
Some of the primary genes impacted are COL1A1 (matrix), VEGFA (angiogenesis), IL6 (inflammation), and SOD2 (oxidative defense)
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating
Cytokine Responses of TNF-, IL-6, and IL-10 in G6PD-Deficient Infants
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