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Semaglutide is the proven GLP-1 agonist that established the modern obesity pharmacotherapy era
Kaplowitz, N., Aw, T
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Emerging evidence suggests that collagen-derived peptides may positively influence these pathological processes by modulating extracellular matrix remodelling and adipose tissue function, reducing oxidative stress, improving lipid and glucose metabolism, enhancing insulin sensitivity and supporting intestinal barrier integrity, through mechanisms involving PPAR-/, AMPK, mTOR, DPP-IV and ACE signalling pathways, as well as modulation of gut microbiota and oxidative stress (Reference Giangregorio, Mosconi and Debellis28)
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