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Class I ferroptosis inducers (FINs), including sorafenib, sulfasalazine, erastin, and its analog imidazole ketone erastin, inhibit system Xc-, disturb the synthesis of GSH, and subsequently deplete GSH to suppress the GPX4 enzyme activity

These results suggest that RRM2 may affect the cycle progression of thyroid cancer cells mainly by regulating the transition from G1 to S phase

5-Ethynyl-2-deoxyuridine (EdU) incorporation assay DNA synthesis was assayed using the BeyoClick EdU Cell Proliferation Kit (Beyotime) according to the manufacturers instructions

Westerfield, M

Protocol caution Although your clinic dispenses peptides, its crucial to emphasise that FOXO4-DRI remains research only