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Due to their programmability and strictly following the principle of complementary base pairing, DNA nanodevices can be assembled into different geometries to cross the cell membrane into cells to exert their functions ( In general, we need to reprogram DNA complementary sequences by AI so that they can be assembled de novo from covalently bonded carbon chains (Nummelin et al., 2018), further forming more nanoscale devices that are then integrated into living cells for study using synthetic biology approaches ( in situ assembly of G-quadruplex DNAzyme nanowires to quantify different CpG methylation targets of different human cancer cells and found that this DNA nanodevice could discriminate the methylated expression of CPGs in lung cancer and precancerous tissues (Wang et al., 2022)
Neuroscience 582:134145
Liang, J
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