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The most common side effects are mild: slight water retention, flushing, or injection site reactions
Targeting antioxidants to mitochondria: a new therapeutic direction
While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]
Those are two of the stories out there
About Vitamin B12 Individuals who do not consume animal products or have poor natural absorption may have a vitamin B12 deficiency resulting in fatigue, poor sleep, and low concentration
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