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The compounds listed in Table S4, tested at various times and at concentrations with statistically significant effect, induce eryptosis dependent on calcium, ceramide, and ROS
Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks
Presently, v6pep is undergoing clinical trials
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5E, F and Supplementary Fig
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