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Strikingly, our GSEA analysis also showed that ablation of Gclc in FoB displayed a similar increase in mTORC1 signaling genes compared to Gclc fl/fl FoB and Gclc fl/fl MZB (Fig

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C677T: G/G: typical function A/G: enzyme function decreased by ~40% A/A: enzyme function decreased by 7080% A1298C: T/T: typical function G/T: slightly decreased function G/G: enzyme function decreased by ~20% Are there other MTHFR variants that matter