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The honest framing has three parts: This is mechanistic reasoning, not a demonstrated effect

Savignac et al., 2014

Growth Hormone Receptor Upregulation (More Healing Signal): It significantly increases GH receptor expression in tendon and muscle cells, amplifying the downstream effects of growth hormone and IGF-1 your bodys primary tissue-rebuilding hormones

Given that EtOH-induced mitochondrial dysfunction and ER stress are intimately involved in the pathogenesis of ALD, future studies to examine these pathways under the current experimental setting will provide important mechanistic information underlying the protection seen in GCLM KO mice

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