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Mechanistic studies further support the rationale for combination therapy

Key legal arguments and prior art claims BPI Labs contends that the claims in Lilly patent are obvious based on prior publications by researchers including Alsina-Fernandez, DiMarchi, and Lau

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Abbreviations MSM: methyl sulphonyl methane Vit C: vitamin C GPx: glutathione peroxidise GST: glutathione transferase GR: glutathione reductase HO: heme oxygenase ROS: reactive oxygen species RNS: reactive nitrogen species NO: nitric oxide CO: carbon monoxide GSH: glutathione