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Upon APAP overdose, excessive NAPQI can also induce the formation of OH free radicals and react with NO to form ONOO [51]
Nishioka T, Kawabata J, Aoyama Y
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The study indicates this may not be because the patients aren't producing enough glutathione, it may be because glutathione is being used at a higher rate in patients with type II diabetes
It can be a symptom of rare but serious side effects like pancreatitis or gallbladder problems
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