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When the circulating lymphocytes no longer have to expend massive amounts of energy synthesizing their own emergency glutathione to survive, they can return to their normal, regulatory functions

If a dose increase causes intolerable GI symptoms, the Phase 2 protocol explicitly permitted returning to the prior dose level and waiting a full 4 weeks before re-attempting escalation

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Potential Ozempic advantage: The gradual titration schedule may help patients adjust more smoothly