Oral semaglutide at doses of up to 14 mg daily is approved for T2D and doses as high as 50 mg daily have been evaluated for weight loss, with 25 mg daily filed for approval for the treatment of obesity
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These findings should be positioned as hypothesis-generating, and their clinical translatability requires validation in larger samples with pre-specified endpoints (113116)
SGLT2 inhibitors (e.g., empagliflozin, canagliflozin, dapagliflozin) work by blocking the SGLT2 protein in the kidneys, increasing sugar excretion and reducing blood sugar levels without insulin