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c-fos gene expression has been identified to be significantly lower in leiomyoma cells as compared to normal myometrium which is consistent with the previous study that has suggested that a decrease in the smooth muscle cells progenitors could have contributed to the formation of UF ( c-fos expression in leiomyoma cells induced by SB is associated with its antiproliferative actions ( The higher incidence of UF and the greater fibroid size during the first trimester of pregnancy have suggested the role of hCG in the pathogenesis of UF ( SB has also been observed to down-regulate the expression of IGF-I in leiomyoma cells which were overexpressed in UF as compared to normal myometrium (Prrizas et al., 1997)

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