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Timing: Evening administration preferred
If injectable tirzepatide costs $400/month and produces 2% body weight loss per month, that is $200 per percentage point lost
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Multivitamins including vitamin D may also be a good idea
Neutralizing IL-1 or IL-18 (the inflammasome products) is another approach: Anakinra (IL-1 receptor antagonist) has been used off-label in systemic inflammation settings and is attractive for short-term use around surgery to DAMPsen the IL-1 surge (115)
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