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Pro-inflammatory cytokines stimulate corticotropin-releasing hormone (CRH) secretion and impair glucocorticoid receptor signaling, resulting in diminished negative feedback and sustained hypercortisolemia
Horiuchi M, Hinderer CJ, Shankle HN, Hayashi PM, Chichester JA, Kissel C, et al
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Peptides break down in the gut, so the sublingual route is preferred for consistent systemic delivery without the need for injection
Rich, D
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