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After accounting for study design differences across trials using weighting, the maximum SMD across covariates decreased from 0.37 before weighting to 0.07 after weighting, indicating a balanced distribution of weighted covariates between tirzepatide and comparator arms (Table 1, Supplemental Table 10)

Another 8% had purity below 90%, meaning up to 10% of the vial contained unknown impurities

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The main concern over a vitamin B12 deficiency is that it can lead to anemia, a condition where there are fewer healthy red blood cells