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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2
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Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier
Rarely, patients report mild digestive upset or headache
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