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Rybelsus is a once-daily tablet, whereas Ozempic is a once-weekly injection

Greater lowering of mean HbA1c (85% at baseline) was achieved with 18 mg liraglutide (150%) and 12 mg liraglutide (124%) than with sitagliptin (090%)

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doi: 10.1038/s41598-021-84122-y 189 KohRHJinYKimJHwangNS

Hills research does suggest that, while the API is a minor cost component compared to the pen in an injectable formulation, the need to dose daily for a higher API load in a pill makes orals pricier to manufacture than injectables, further raising the competitive advantage of manufacturing small molecule alternatives, such as Lillys orforglipron