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26 HuangJ.WillemsP.WeiB.TianC.FerreiraR

175 (7), 17801795.e19

These changes in substrate levels drive the isocitrate dehydrogenase (IDH)-mediated reductive carboxylation of -KG to produce isocitrate and citrate, which are then transported out of the mitochondria to participate in the synthesis of biomolecules such as lipids and amino acids [135]