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Individual variability is significant and depends on starting weight, metabolic factors, medication adherence, dose optimization, lifestyle factors, and genetic variables
Sources Comparative review of semaglutide and tirzepatide mechanisms (Pharmacological Research, ScienceDirect) A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity (Diabetes, American Diabetes Association) GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models (PMC) Anorectic and aversive effects of GLP-1 receptor agonism mediated by brainstem CCK neurons, modulated by GIP (PMC) Head-to-Head Trial Compares Weight Loss Drugs (Weill Cornell Medicine Newsroom, reporting NEJM SURMOUNT-5) Head-to-head comparison of tirzepatide and semaglutide for weight loss: systematic review and meta-analysis (PubMed) Are You a GLP-1 Nonresponder
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Scientists Are Studying GLP-1s for Broader Health Benefits in Bipolar Disorder These include metabolic liver disease, polycystic ovary syndrome (PCOS), and binge eating disorder, says Roger McIntyre, MD, a professor of psychiatry and pharmacology at the University of Toronto and head of the Mood Disorders Psychopharmacology Unit of the University Health Network in Toronto
2013;8(11):e74883
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