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That increased pressure and prolonged acid exposure cause reflux in 1015% of patients, especially during dose increases

doi: 10.1016/j.dsx.2022.102427 11 AnderbergRHRichardJEHanssonCNissbrandtHBergquistFSkibickaKP

In data comparing results from weeks 1-4 and 5-8 (with semaglutide dose doubling from 0.25mg/week to 0.5mg/week over that interval) a clear dose-sensitivity was seen in most measures: the beneficial impacts of the medication (measured by effect size) were greater at the higher dose

Under normal circumstances, the mouth is protected by a delicately balanced bio-system of enzymes and lubricants in saliva, allowing beneficial bacteria to flourish and inhibit the growth of pathogenic bacteria

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