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But around 2010 as Sikiric was conducting rat studies peptides came onto their radar

Well-designed clinical trials in humans are needed

Normally microglia are neuroprotective, cleaning out debris that may contribute to neurodegenerative diseases or damage from ischemic stroke, but in the case of TBI they can become overactivated and exacerbate neuroinflammation (with upregulated TNFa, IL-6, C3, NK-kB, CD68, etc), and vascular changes can result in headaches, neurovascular flow changes, impaired lymphatic flow, blood-brain barrier disruption, activation of pro-inflammatory pathways, neuronal death, hyperexcitability, and disrupted synaptic connections

Before reconstitution, store these vials in the freezer at -20C for maximum stability

Some patients see changes earlier