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In contrast, the m 6 A demethylase ALKBH5 binds to specific m 6 A modification sites in the 3-UTR region of ACSL4 mRNA, promoting the stability of ACSL4 mRNA, thereby upregulating ACSL4 expression and promoting the ferroptosis process [86]

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Nrf2 activators like sulforaphane have a potential role with dual antiviral and anti-inflammatory properties in the management of viral pneumonia, a serious complication in COVID-19 disease (Bousquet et al., 2020