Mechanistically, T3 acts to alter the BA composition by targeting CYP8B1, a sterol 12-hydroxylase required for CA synthesis, and then the subsequently altered BA profiles, particularly the increased non-12-OH FXR-antagonistic BAs, potentiates the GLP-1 production and insulin secretion by repressing FXR signaling
1 2 Jacques, F., Rippa, S., Perrin, Y., Physiology of L-carnitine in plants in light of the knowledge in animals and microorganisms , Plant Science , n o 247, 432-440 (PMID 30080631, DOI Ramsay, R., Arduini, A., The carnitine acyltransferases and their role in modulating acyl-CoA pools , Archives of Biochemistry and Biophysics , vol
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