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This work was supported in part by JSPS KAKENHI Grant Numbers JP23K27304, JP23K20040, JP23K17389, JP21H05262 and 24K01446 to KeH, 25K08844 and 25H01419 to ES, a grant from the Japan Agency for Medical Research and Development (AMED) (JP24ak0101182s0104 and JP24gm1510012s0202) to KeH, JST CREST to KeH and Program for the Advancement of Next-Generation Research Projects (Keio University), Academic Development Fund (Keio University Academic Development Funds) and Fukuzawa Fund (Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research) to KeH and KoH was supported by the WPI-Bio2Q STaMP program (WPI-Bio2Q, Keio University)

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