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Moreover, resistance to auranofin may occur due to the aberrant expression of multiple drug transporters (e.g., SLC22A1, SLC47A1, SLCO1B1, and ABCBs) in cancer cells [239]

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Loren Pickart, who pioneered much of the research, suggested that GHK-Cu levels decrease significantly with age (1), although the exact extent of this decline varies across studies